The first picture, taken from 9th and Mass looking up Mass towards Dupont. While the hotel's design is only now underway, I believe it's anticipated that the main entrance (bag check, valet, and that sort of stuff) will be on Mass. My understanding is that the tall office building on the corner will stay and is not part of the hotel development.
A lot of vacant buildings and empty lots define the landscape currently (in part due to land acquisition for the hotel), so the hotel will bring some much-needed life to lower 9th. Central Lock and Key, the blue-sided building in the picture above, is one longtime survivor that will be displaced by the new hotel.